Introduction: Tropical Spastic Paraparesis


Tropical Spastic Paraparesis: For several decades the term “tropical spastic paraparesis” (TSP) was used to describe a chronic and progressive clinical syndrome that affected adults living in equatorial areas of the world. This condition was initially thought to be associated with infectious agents (such as Treponema pertenue and Treponema pallidum which cause inflammation of the central nervous system) and with chronic nutritional deficiencies (such as avitaminosis) or exposure to potentially toxic foods (such as bitter cassava). Neurological and modern neuroepidemiological studies found that in some individuals no one cause could explain the progressive weakness, sensory disturbance, and sphincter dysfunction that affected individuals with TSP. In spite of public health programs created to eradicate the above-mentioned infectious and nutritional conditions in the tropics, large numbers of people continued to be affected. During the mid-1980's, an important association was established between the first human retrovirus-human T-cell lymphotrophic virus type 1 (also known as HTLV-1)-and idiopathic TSP (idiopathic means of unknown origin). Since then, this condition has been named HTLV-1 associated myelopathy/ tropical spastic paraparesis or HAM/TSP and scientists now understand that it is a condition caused by a virus that results in immune dysfunction. 1

Researching symptoms of Tropical Spastic Paraparesis: Further information about the symptoms of Tropical Spastic Paraparesis is available including a list of symptoms of Tropical Spastic Paraparesis, or alternatively return to research other symptoms in the symptom center.

Treatments for Tropical Spastic Paraparesis: Various information is available about treatments available for Tropical Spastic Paraparesis, current research about Tropical Spastic Paraparesis treatments, or research treatments for other diseases.

Causes of Tropical Spastic Paraparesis: Research more detailed information about the causes of Tropical Spastic Paraparesis, other possibly hidden causes of Tropical Spastic Paraparesis, or other general information about Tropical Spastic Paraparesis.

Statistics and Tropical Spastic Paraparesis: Various sources and calculations are available in statistics about Tropical Spastic Paraparesis, and you can also research other medical statistics in our statistics center.

         Contents for Tropical Spastic Paraparesis:

1. excerpt from NINDS Tropical Spastic Paraparesis Information Page: NINDS

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