Medical Dictionary: Mosaicism

Mosaicism: Having two sets of cells with different genes
Introduction: The idea of mosaicism is that some people have two (or more) sets of cells with slightly different DNA. This is actually quite common with minor DNA differences (e.g. everyone's T-cells have varying DNA), but mosaicism is only of clinical interest when one set of cells has a particular genetic disease or chromosome disease, but the other set of cells has normal DNA. See also germinal mosaicism.
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Mosaicism: Another name for Germinal mosaicism.
Mosaicism (condition): Very rare genetic disease type where people have two types of cells
Mosaicism (condition): Sometimes even an autosomal dominant disease can arise surprisingly when neither parent has the disease. This can be due to a mutation (see sporadic genetic disease), but need not be, and it can also be due to "germinal mosaicism". This is a condition where one parent's gamete cells have the genetic defect, whereas their normal cells do not. These conditions are very rare.

See also articles Introduction to Genetics and Introduction to Genetic Diseases.

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