Medical Dictionary: Monogenic


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Monogenic: Diseases affected by only one gene
Introduction: A monogenic disease is affected only by a single gene. This is typical of Mendelian diseases or the truly genetic diseases. The opposite of a monogenic disease is a polygenic disease, affected by multiple genes (or a non-genetic disease not affected by genes at all). The inheritance pattern of a monogenic disease depends on whether it is autosomal dominant, autosomal recessive, x-linked dominant, x-linked recessive, or y-linked. Also related but not truly Mendelian are some of the rarer inheritance patterns (e.g. mosaicism, anticipation, triplet repeat).
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