Conditions by Prevalence


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Conditions here are listed according to prevalence, which is the estimated number of people who have the condition at a given time. This measure may differ from the incidence of the condition, which refers to new annual cases, and the rates below do not include incidence data in computations. For comparison, see conditions by people affected (prevalence or incidence), and conditions by incidence. See also details about prevalence and incidence statistics for more information. In most cases, rates refer to the USA or other industrialized nations.

Condition Percent Rate US People Data
1. Respiratory conditions 78.90% 1 in 1 214.6 million 78.9 per 100 (NHIS96)
2. Cytomegalovirus 50.00% 1 in 2 136 million 50% approximately; almost half of young adults (NIAID)
3. Cold sores 50.00% 1 in 2 136 million estimated 50 to 80% of Americans have HSV-1
4. Refractive Eye Disorders 44.12% 1 in 2 120 million 120 million people
5. High Cholesterol 37.13% 1 in 3 101 million estimated 101 million Americans have cholesterol >= 200 mg/dL (CDC)
6. Overweight 35.70% 1 in 3 97.1 million 97.1 million American adults
7. Chronic Illness 33.09% 1 in 3 90 million 90 million people in USA (CDC)
8. Myopia 25.74% 1 in 3 70 million 70 million Americans; over 25 percent of all adult Americans.
9. Insulin Resistance 25.00% 1 in 4 68 million about 25% of the USA population have insulin resistance
10. Metabolic Syndrome 25.00% 1 in 4 68 million about 25% of the USA population have insulin resistance
11. Genital herpes 24.63% 1 in 4 67 million 67 million people (NIAID)
12. Sexually Transmitted Diseases 23.90% 1 in 4 65 million 65 million people living with an incurable STD (CDC)
13. Cardiovascular diseases 22.72% 1 in 4 61.8 million 61,800,000 cases in the USA (American Heart Association, 2004)
14. Hyperopia 22.40% 1 in 4 60.9 million 22.4% of population self-reported having long-sightedness in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
15. Smoking 22.30% 1 in 4 60.7 million 22.3% of Americans smoke (CDC); 23 million American women smoke (NHLBI)
16. Toxoplasmosis 22.06% 1 in 4 60 million More than 60 million in USA but few have symptoms (DPD)
17. Digestive Diseases 22.06% 1 in 4 60 million 60 to 70 million cases in the USA 1985 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447)
18. Epstein-Barr virus 20.00% 1 in 5 54.4 million as many as 20% of people carry the virus in their throats
19. Hypertension 18.38% 1 in 5 50 million 50 million Americans (NHLBI); 217 per 1000 (NHIS95)
20. Dandruff 18.38% 1 in 5 50 million 50 million
21. Allergies 18.38% 1 in 5 50 million 50-60 million (NIAID); 9-16% (NIAID); 50 million cases annually (NIAID); 10% of American women (NHWIC); 8,526,000 children respiratory allergies (NHIS-97); 7,304,000 children non-respiratory allergies (NHIS-97)
22. Headache 16.54% 1 in 6 45 million 45 million Americans get chronic headaches. 20 million American women (NWHIC).
23. Chronic headache 16.54% 1 in 6 45 million estimated 45 million Americans (NINDS)
24. Astigmatism 16.54% 1 in 6 45 million 45 million Americans (dubious estimate based on "two thirds of people with myopia also have astigmatism")
25. Anxiety Disorders 16.40% 1 in 6 44.6 million estimated 16.4% adults (USSG); 19.1 million American adults (NIMH); 13.3% of adults (NIMH)
26. Impaired glucose tolerance 15.07% 1 in 6 41 million estimated 41 million people aged 40-74 have pre-diabetes in the US 1988-94 (National Diabetes Statistics fact sheet, NIDDK, 2003)
27. Premenstrual syndrome 15.00% 1 in 6 40.8 million 30-40% women suffer some impairment of daily activity (NWHIC); 75% women have some symptoms; 3-8% women have severe PMS (NWHIC).
28. Orthopedic disorders 14.90% 1 in 6 40.5 million 149 per 1000 - NHIS95
29. Sleep disorders 14.71% 1 in 6 40 million approximately 40 million Americans (NHLBI)
30. Obesity 14.63% 1 in 6 39.8 million 39.8 million American adults; more than 57% of American adults are overweight (CDC)
31. Arthritis 13.60% 1 in 7 37 million 37 million Americans (NIAMS)
32. Sinusitis 13.60% 1 in 7 37 million 37 million annually in the USA; 33 million reported to CDC (NIAID)
33. Hay fever 12.87% 1 in 7 35 million 35 million Americans (NIAID: pollen allergies)
34. Pollen allergy 12.87% 1 in 7 35 million estimated 35 million Americans with pollen allergies (NIAID)
35. Chronic Sinusitis 12.60% 1 in 7 34.3 million 12.6% (NIAID); 152 per 1000 - NHIS95
36. Insomnia 11.76% 1 in 8 32 million 32 million (unreliable estimate)
37. Chronic lower respiratory diseases 11.76% 1 in 8 32 million estimated 32 million including 15 million undiagnosed
38. Lung conditions 11.03% 1 in 9 30 million more than 30 million Americans with chronic lung diseases (NWHIC)
39. Impotence 11.03% 1 in 9 30 million 30 million men (NIDDK)
40. Lactose Intolerance 11.03% 1 in 9 30 million 30 million people to 50 million people (NIDDK 1994); about 25% of population (1994/NIDDK)
41. Osteoporosis 10.29% 1 in 9 28 million 28 million Americans (10 million with osteoporosis; 18 million with low bone mass); eight million American women and 2 million men (NWHIC)
42. Migraine 10.29% 1 in 9 28 million 28 million Americans (NINDS)
43. Moles 10.00% 1 in 10 27.2 million common; most people have 10-40 moles.
44. Molluscum contagiosum 10.00% 1 in 10 27.2 million Common.
45. Scabies 10.00% 1 in 10 27.2 million common
46. Retroverted uterus 10.00% 1 in 10 27.2 million about 1 in 5 women
47. Subfertility 10.00% 1 in 10 27.2 million about 1 in 10 couples
48. Allergic rhinitis 10.00% 1 in 10 27.2 million 10% of the population with allergic rhinitis/hay fever in the US (Mayo Clinic)
49. Otosclerosis 10.00% 1 in 10 27.2 million as many as 10% of Caucasians have the condition but most do not get symptoms; about 1 in 100 cases actually lose hearing from otosclerosis
50. Extra Nipples 10.00% 1 in 10 27.2 million about 1 in 10 people but most are small and mistaken for freckles or moles
51. Depressive disorders 9.50% 1 in 10 25.8 million 9.5 percent of adult Americans (NIMH)
52. Rare diseases 9.19% 1 in 10 25 million about 25 million Americans (ORD); each disease less than 200,000 Americans by definition.
53. Presbyopia 9.00% 1 in 11 24.5 million 9.0% of population self-reported having presbyopia in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
54. Back Impairment 8.50% 1 in 11 23.1 million 85 per 1000 - NHIS95 (deformity or orthopedic impairment of back)
55. Heart disease 8.09% 1 in 12 22 million 22 million adults in the US 2000 (Centers for Disease Control and Prevention)
56. Hearing Impairment 8.09% 1 in 12 22 million 22 million; 158 per 1000 (NHIS95)
57. Thyroid disorders 7.35% 1 in 13 20 million 20 million Americans (NWHIC)
58. Human Papillomavirus 7.35% 1 in 13 20 million 20 million Americans currently infected (NIAID; CDC 2001)
59. Osteoarthritis 7.35% 1 in 13 20 million 20 million people (NIAMS); more than 16 million people (NWHIC)
60. Mood disorders 7.10% 1 in 14 19.3 million estimated 7.1% adults (USSG)
61. Ischemic heart disease 6.80% 1 in 14 18.5 million 68 per 1000 (NHIS95)
62. Sleep apnea 6.62% 1 in 15 18 million estimated 18 million Americans (NHLBI)
63. Asthma 6.40% 1 in 15 17.4 million 6.4% USA (NIAID); 17 million Americans (NIAID) including 5 million children; 8.1 million children (NHIS-97), 51 per 1000 - NHIS95; 14.5 million; 5% of population (NWHIC); 14.9 million in 1995 (NHLBI)
64. Acne 6.25% 1 in 16 17 million 17 million Americans, almost 85% of people 12-24 years of age.
65. Diabetes 5.88% 1 in 17 16 million 16 million Americans with 10.3 million diagnosed and 8.1 million women (NWHIC); 65 per 1000 - NHIS95; 8 million - perhaps 16 million if include not-yet-diagnosed.
66. Type 2 diabetes 5.88% 1 in 17 16 million 16 million Americans (NWHIC, includes undiagnosed); 7.2 million (actually diagnosed)
67. Gallstones 5.88% 1 in 17 16 million 16 to 22 million people in the USA 1976-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, NIDDK, 1994)
68. Alcoholism 5.55% 1 in 18 15.1 million estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA)
69. Alcohol abuse 5.55% 1 in 18 15.1 million estimated 15.1 million people: 15.1 million alcohol-abusing or alcohol-dependent individuals and 4.6 million are women (NWHIC); nearly 14 million Americans (NIAAA)
70. Eczema 5.51% 1 in 18 15 million 15 million people (NIAMS); 10% infants/children estimated (NIAMS); 9% (NIAID); 8.5 million
71. Gynecomastia 5.51% 1 in 18 15 million 15 million - 15% of adult men to some extent (unreliable estimate)
72. Heartburn 5.51% 1 in 18 15 million 15 million Americans have it daily (NIDDK)
73. Depression 5.30% 1 in 18 14.4 million estimated 5.3% adults (USSG); 17 million people; approximately 4% of adolescents get seriously depressed (NIMH); annually 12% of women ; 7% of men; lifetime risk of an episode for women 20%. 3-4 million men USA.
74. Arrhythmias 5.30% 1 in 18 14.4 million 53 per 1000 (NHIS95: heart rhythm disorders); 21 per 1000 (NHIS95: heart murmurs)
75. Urinary stones 5.20% 1 in 19 14.1 million 5.2% of adults in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003)
76. Raynaud's phenomenon 5.00% 1 in 20 13.6 million 5-10% (NIAMS estimate). Scleroderma-related disorders including Raynaud's phenomenon between 250,000 and 992,500.
77. Uterine fibroids 5.00% 1 in 20 13.6 million 10-20% women (NWHIC)
78. Endometriosis 5.00% 1 in 20 13.6 million 10 to 20 percent of American women of childbearing age have endometriosis (NIDCD); up to 2 million women in the UK.
79. Red-green color blindness 5.00% 1 in 20 13.6 million about 10% of males
80. Chronic Obstructive Pulmonary Disease 4.96% 1 in 20 13.5 million 13.5 million Americans (NHLBI)
81. Coronary heart disease 4.85% 1 in 20 13.2 million estimated 13,200,000 in the USA 2001 (American Heart Association, 2004)
82. Urinary Incontinence 4.78% 1 in 20 13 million 13 million adults (NIDDK); 1 in 10 over 65 (NWHIC).
83. Rosacea 4.78% 1 in 20 13 million 13 million people in the United States (NIAMS)
84. Varicose veins 4.50% 1 in 22 12.2 million 45 per 1000 (NHIS95)
85. Tinnitus 4.50% 1 in 22 12.2 million 45 per 1000 (NHIS95); 12 million Americans
86. Chronic Bronchitis 4.45% 1 in 22 12.1 million 12.1 million Americans (NHLBI)
87. Obstructive sleep apnea 4.41% 1 in 22 12 million 12 million Americans
88. Genetic Disease 4.41% 1 in 22 12 million 12 million Americans - unreliable estimate, (perhaps 2.5% births)
89. Phobias 4.23% 1 in 23 11.5 million 11.5 million adults (NIMH); 8.0% adults (NIMH)
90. Cornea disorders 4.04% 1 in 24 11 million 11,000,000 people experience corneal disorders such as herpes or dry eye in the US (Research to Prevent Blindness, NISE, NSF)
91. Dysthymia 4.01% 1 in 24 10.9 million about 10.9 million American adults (NIMH); estimated 1.6% adults (USSG)
92. Presbycusis 3.90% 1 in 25 10.6 million 30-35% over 65 have some hearing loss, 40-50% over 70.
93. Hemorrhoids 3.82% 1 in 26 10.4 million 10.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
94. Latent tuberculosis 3.68% 1 in 27 10 million estimated 10 to 15 million people in USA (NIAID)
95. Jaw conditions 3.68% 1 in 27 10 million estimated 10 million women in the USA (NWHIC)
96. Age-related macular degeneration 3.68% 1 in 27 10 million 10,000,000 people have reduced vision due to age-related macular degeneration in the US (Research to Prevent Blindness, NISE, NSF)
97. Indigestion 3.50% 1 in 28 9.5 million 35 per 1000 - NHIS95 (frequent indigestion)
98. Dermatitis 3.30% 1 in 30 8 million 33 per 1000 (NHIS95)
99. Insect sting allergies 3.30% 1 in 30 8 million 3.3% (NIAID); up to 5% of the population (NHWIC)
100. Bursitis 3.20% 1 in 31 8.7 million 32 per 1000 (NHIS95)
101. Autoimmune diseases 3.13% 1 in 31 8.5 million 8,511,845 people in the USA 1996 1
102. Dry skin 3.10% 1 in 32 8.4 million 31 per 1000 - NHIS95 (trouble with dry/itching skin)
103. Disc Disorders 3.10% 1 in 32 8.4 million 31 per 1000 (NHIS95: intervertebrate disc disorders)
104. Paget's disease of bone 3.00% 1 in 33 8.2 million about 3% of people aged over 40; 10% by age 80.
105. Congenital conditions 3.00% 1 in 33 8.2 million 3-4% of babies (NWHIC)
106. Gastroesophageal Reflux Disease 3.00% 1 in 33 8.2 million 3-7% of the population in the USA 1985 for "GERD and related esophageal disorders" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
107. Urinary tract infections (child) 3.00% 1 in 33 8.2 million 3% of girls and 1% of boys before age 11
108. Cerebrovascular Conditions 3.00% 1 in 33 8.2 million 30 per 1000 - NHIS95
109. Heart attack 2.76% 1 in 36 7.5 million 7.5 million people with AMI (NHLBI)
110. Squint 2.76% 1 in 36 7.5 million 7,500,000 people suffer from strabismus or cross eyes in the US (Research to Prevent Blindness, NISE, NSF)
111. Kidney disease 2.72% 1 in 36 7.4 million 7.4 million adults in the USA 1988-94 (American Journal of Kidney Disease)
112. Prostate conditions 2.60% 1 in 38 7.1 million 52 per 1000 men - NHIS95; 2,803 million men (NIDDK)
113. Ingrown nails 2.60% 1 in 38 7.1 million 26 per 1000 - NHIS95 (trouble with ingrown nails)
114. Callus 2.50% 1 in 40 6.8 million 25 per 1000 - NHIS95 (trouble with corns or calluses)
115. Corns 2.50% 1 in 40 6.8 million 25 per 1000 - NHIS95 (trouble with corns or calluses)
116. Polycystic ovary syndrome 2.50% 1 in 40 6.8 million 5-10% women of childbearing age (20-40); 30% of women have some PCOS symptoms (NWHIC).
117. Fecal incontinence 2.39% 1 in 41 6.5 million 6.5 million Americans
118. Angina 2.35% 1 in 42 6.4 million 6.4 million Americans (NHLBI)
119. Specific phobias 2.32% 1 in 43 6.3 million estimated 6.3 million adult Americans (NIMH); estimated 8.3% adults (USSG)
120. Cystitis 2.28% 1 in 43 6.2 million 6.2 million adults self-reported having a bladder infection for more than 3 months in the US 1988-1994 (Weighted Analysis of 1988-1994, NHANES, NIDDK)
121. Infertility 2.24% 1 in 44 6.1 million 6.1 million people in 1997 (NWHIC); 5.3 million Americans or 9% of reproductive age (NWHIC/American Society for Reproductive Medicine)
122. Back pain 2.21% 1 in 45 6 million 6 million cases annually (unreliable estimate)
123. Nonulcer dyspepsia 2.13% 1 in 46 5.8 million 5.8 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994)
124. Anti-Social Personality Disorder 2.10% 1 in 47 5.7 million estimated 2.1% adults (USSG)
125. Cataracts 2.02% 1 in 49 5.5 million 5,500,000 people have a cataract interfering with their vision in the US (Research to Prevent Blindness, NISE, NSF)
126. Psoriasis 2.02% 1 in 49 5.5 million 5.5 million people in the USA (NIAMS)
127. Autoimmune thyroid diseases 2.00% 1 in 50 5.4 million 4 out of 100 women some type of autoimmune thyroid disease
128. Borderline Personality Disorder 2.00% 1 in 50 5.4 million 2 percent of adults (NIMH)
129. Cyclic vomiting syndrome 2.00% 1 in 50 5.4 million 1 in 50 children (perhaps)
130. Penicillin allergy 2.00% 1 in 50 5.4 million 2-3% of people (2-3% of hospitalized patients)
131. Mitral-valve prolapse 2.00% 1 in 50 5.4 million 2% of the adult population (NHLBI estimate)
132. Social phobia 1.95% 1 in 51 5.3 million 5.3 million adult Americans (NIMH); 3.7% adults (NIMH); 2.0% adults (USSG)
133. Bunions 1.92% 1 in 51 5.2 million 19.25 per 1000 - NHIS95 (trouble with bunions)
134. Post-traumatic stress disorder 1.91% 1 in 52 5.2 million 5.2 million adult Americans (NIMH); 3.6% adults (NIMH); about 30% of war veterans.
135. Female genital disorders 1.90% 1 in 52 5.2 million 38 per 1000 women (NHIS95)
136. Irritable bowel syndrome 1.84% 1 in 54 5 million 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, US Government Printing Office, 1994); 11 per 1000 (NHIS95)
137. Peptic Ulcer 1.84% 1 in 54 5 million 5 million in the USA 1987 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, 1994)
138. Eating disorders 1.84% 1 in 54 5 million 5 million women (NWHIC); 1-4% of young women
139. Heart failure 1.76% 1 in 56 4.8 million 4.8 million (NHLBI); 2 to 3 million Americans (NHLBI)
140. Congestive Heart Failure 1.76% 1 in 56 4.8 million 4.8 million Americans (NHLBI); 2% age 40-59; 5% age 60-69; 10% over 70's
141. Atherosclerosis 1.70% 1 in 58 4.6 million 17 per 1000 - NHIS95
142. Learning disabilities 1.69% 1 in 59 4.6 million 4.6 million children (NHIS-97)
143. Stroke 1.69% 1 in 59 4.6 million estimated 4.6 million (NHLBI)
144. Abdominal Hernia 1.65% 1 in 60 4.5 million 4.5 million people in the USA 1988-90 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
145. Constipation 1.62% 1 in 61 4.4 million 4.4 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
146. Edema 1.60% 1 in 62 4.4 million 1.6% of population self-reported having oedema in Australia 2001 (ABS 2001 National Health Survey, Australia’s Health 2004, AIHW)
147. Tachycardia 1.60% 1 in 62 4.4 million 16 per 1000 (NHIS95)
148. Kidney conditions 1.50% 1 in 66 4.1 million 15 per 1000 (NHIS95: "kidney trouble")
149. Alzheimer's Disease 1.47% 1 in 68 4 million more than 4 million Americans (CDC); estimated 4 million people in the U.S (NHWIC)
150. Drug abuse 1.47% 1 in 68 4 million more than 4 million women need treatment for drug abuse (NWHIC)
151. Generalized anxiety disorder 1.47% 1 in 68 4 million 4 million adult Americans (NIMH); 2.8% adults (NIMH); estimated 3.4% adults (USSG)
152. Chronic Hepatitis C 1.47% 1 in 68 4 million Almost 4 million Americans have antibodies indicating infection or prior exposure (NIDDK).
153. Deafness 1.47% 1 in 68 4 million 4 million people (unreliable estimate)
154. Fibromyalgia 1.36% 1 in 73 3.7 million 3.7 million Americans (NIAMS)
155. Color blindness 1.30% 1 in 76 3.5 million 13 per 1000 - NHIS95
156. Anemia 1.29% 1 in 77 3.5 million 3.5 million (NHLBI)
157. Attention Deficit Hyperactivity Disorder 1.21% 1 in 82 3.3 million 3.3 million children have ADD in USA (NHIS-97); estimated 2 million American children; 3 to 5 percent of all children (NIMH).
158. Obsessive-compulsive disorder 1.21% 1 in 82 3.3 million 3.3 million adult Americans (NIMH); 2.3% adults (NIMH); 1 in 50 people (NWHIC); 2.4% adults (USSG)
159. Bipolar disorder 1.20% 1 in 83 3.3 million 1.2 percent of the population; 2.3 million adult Americans (NIMH)
160. Agoraphobia 1.18% 1 in 84 3.2 million approximately 3.2 million American adults ages 18 to 54 (NIMH); estimated 4.9% adults (USSG)
161. Graves Disease 1.12% 1 in 89 3 million 3,048,636 people in the USA 1996 1; 1.3 million people (NWHIC)
162. Von Willebrand disease 1.10% 1 in 90 3 million estimated 3 million mostly undiagnosed
163. Open-angle glaucoma 1.10% 1 in 90 3 million about 3 million Americans, many not yet diagnosed.
164. Peanut allergies 1.10% 1 in 90 3 million 3 million Americans (peanut and tree nut combined; NIAID)
165. Dental conditions 1.10% 1 in 90 2 million 1.1 per 100 (NHIS96: acute dental conditions)
166. Stuttering 1.00% 1 in 100 2.7 million about 1% of adults
167. Deuteranopia 1.00% 1 in 100 2.7 million about 1% of white males
168. Protanopia 1.00% 1 in 100 2.7 million about 1% of white males
169. Food allergies 1.00% 1 in 100 2.7 million 1% of the adult population have a true immune reaction to food (NHWIC)
170. Latex allergies 1.00% 1 in 100 2.7 million 1-6% (NIAID)
171. Speech impairment 1.00% 1 in 100 2.7 million 10 per 1000 (NHIS95)
172. Gastritis 0.99% 1 in 100 2.7 million 2.7 million people in the USA 1988 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
173. Rheumatoid arthritis 0.92% 1 in 108 2.5 million 2.5 million Americans (NWHIC); 1% of US population (NIAMS)
174. Paralysis 0.90% 1 in 111 2.4 million 9 per 1000 - NHIS95 (paralysis of extremeties complete/partial)
175. Panic disorder 0.88% 1 in 113 2.4 million approximately 2.4 million Americans (NIMH)
176. Vision Impairment 0.88% 1 in 113 2.4 million 2.4 million Americans
177. Epilepsy 0.85% 1 in 118 2.3 million 2.3 million Americans (CDC)
178. Uveitis 0.85% 1 in 118 2.3 million 2,300,000 people suffer uveitis in the US (Research to Prevent Blindness, NISE, NSF)
179. Schizophrenia 0.81% 1 in 123 2.2 million Approximately 2.2 million American adults (NIMH); estimated 1.3% adults (USSG); more than 2 million Americans
180. Deviated Septum 0.80% 1 in 124 2.2 million 8 per 1000 - NHIS95
181. Glaucoma 0.74% 1 in 136 2 million 2,000,000 people are visually impaired by glaucoma in the US (Research to Prevent Blindness, NISE, NSF)
182. Vitiligo 0.74% 1 in 136 2 million 2 to 5 million people in the USA (1-2% worldwide); 1,059,560 people in the USA 1996 1
183. Diverticular Disease 0.74% 1 in 136 2 million 2 million people in the USA 1983-87 (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
184. Hepatitis C 0.74% 1 in 136 2 million estimated 2 to 5 million HCV chronic carriers
185. Alcoholic liver disease 0.74% 1 in 136 2 million More than 2 million Americans (NIAAA)
186. Emphysema 0.74% 1 in 136 2 million 2 million Americans (NHLBI); 17 per 1000 - NHIS95; 2 million annually
187. Atrial Fibrillation 0.74% 1 in 136 2 million 2 million (NHLBI)
188. Polymyalgia rheumatica 0.70% 1 in 142 1.9 million 700 per 100,000 people over 50.
189. Chronic tonsilitis 0.70% 1 in 142 1.9 million 7 per 1000 - NHIS95 (chronic disease of tonsils or adenoids)
190. Amputation 0.70% 1 in 142 1.9 million 7 per 1000 (NHIS95: excludes toes/fingers only)
191. Binge eating disorder 0.70% 1 in 142 1.9 million 0.7% to 4% of the general population (NWHIC); 2-5% of adults (NIMH); 2% of adults (NIDDK); 2% adults or 1-2 million adults (NWHIC)
192. Retina Conditions 0.66% 1 in 151 1.8 million 1,800,000 people have severely impaired vision because of retinal disease in the US (Research to Prevent Blindness, NISE, NSF)
193. Hepatitis B 0.55% 1 in 181 1.5 million estimated 1.5 million HBV carriers in the U.S. (NWHIC); 417,000 people currently infected (CDC 2001)
194. Bulimia nervosa 0.55% 1 in 181 1.5 million estimated 1.1 to 4.2 percent of females (NIMH); 2-3% of young women (NWHIC)
195. Hashimoto's Thyroiditis 0.55% 1 in 182 1.5 million 1,490,371 adults and 205,159 children in the USA 1996 1
196. Lupus 0.51% 1 in 194 1.4 million 1.4 million people in the United States, 1 in 85 (NWHIC)
197. Wegener's granulomatosis 0.50% 1 in 200 1.4 million uncommon
198. HTLV 0.50% 1 in 200 1.4 million uncommon
199. HTLV-1 0.50% 1 in 200 1.4 million uncommon
200. Peyronie's disease 0.50% 1 in 200 1.4 million 1 per 100 men
201. Sebaceous cyst 0.50% 1 in 200 1.4 million 5 per 1000 - NHIS95
202. Bladder Incontinence (Pregnancy) 0.49% 1 in 203 1.3 million 1-in-3 pregnant women approximately
203. Blindness 0.40% 1 in 247 1.1 million 1,100,000 people are legally blind in the US (Research to Prevent Blindness, NISE, NSF)
204. Celiac Disease 0.40% 1 in 249 1.1 million 1 in 250 Americans estimated rate; actual diagnosis rate is 1 in 4,700 Americans; 1 in 250 in Italy; 1 in 300 in Ireland; 20,000 diagnosed (Reader's Digest Feb 2004)
205. Sjogren's Syndrome 0.37% 1 in 272 1 million 1 to 4 million people with Sjogren’s Syndrome (NIAMS)
206. Connective tissue disorders 0.37% 1 in 272 1 million estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
207. Congenital heart defects 0.37% 1 in 272 1 million 1 million (NHLBI)
208. Aphasia 0.37% 1 in 272 1 million 1 million Americans (NINDS)
209. Hemochromatosis 0.37% 1 in 272 1 million more than 1 million Americans (CDC); 5 per 1000 in Caucasians (NIDDK); 1-in-200 to 1-in-300
210. Parkinson's Disease 0.37% 1 in 272 1 million 1 million people (unreliable estimate)
211. Heritable Disorders of Connective Tissue 0.37% 1 in 272 1 million estimated 1 million people in USA with heritable connective tissue disorder (NIAMS)
212. Selective IgA Deficiency 0.33% 1 in 300 906,666 1 in 300 (NIDCD); 1 in 600 (NIAID); 1 in 333 Caucasians.
213. HIV/AIDS 0.33% 1 in 302 900,000 900,000 Americans (NIAID, quarter are unaware)
214. Interstitial cystitis 0.31% 1 in 321 847,000 847,000 in the USA 1988-1994 (Weighted Analysis of 1988-1994 National Health and Nutrition Survey, 2003)
215. Neuralgia 0.30% 1 in 333 816,000 3 per 1000 - NHIS95 (neuralgia or neuritis unspecified)
216. Scoliosis 0.30% 1 in 333 816,000 3-per-1,000 to 5-per-1000 children (NIAMS)
217. Chronic Hepatitis B 0.28% 1 in 362 750,000 750,000 people in the United States (NIAID)
218. Gout 0.28% 1 in 363 748,000 275 per 100,000 people (NIAMS)
219. Von Hippel-Lindau Disease 0.25% 1 in 400 680,000 rare
220. Zollinger-Ellison syndrome 0.25% 1 in 400 680,000 rare
221. Lichen sclerosis 0.25% 1 in 400 680,000 rare
222. Immune Thrombocytopenic Purpura 0.25% 1 in 400 680,000 rare.
223. Behcet's Disease 0.25% 1 in 400 680,000 rare in the USA; more common in Middle East, Asia, and Japan.
224. Penile candidiasis 0.25% 1 in 400 680,000 rare
225. Ascariasis 0.25% 1 in 400 680,000 rare
226. Zellweger Syndrome 0.25% 1 in 400 680,000 rare
227. Congenital SMA with arthrogryposis 0.25% 1 in 400 680,000 rare
228. Agenesis of the corpus callosum 0.25% 1 in 400 680,000 rare
229. Aicardi syndrome 0.25% 1 in 400 680,000 rare
230. Empty Sella Syndrome 0.25% 1 in 400 680,000 rare
231. Hydranencephaly 0.25% 1 in 400 680,000 rare
232. Klippel Feil Syndrome 0.25% 1 in 400 680,000 rare
233. Mobius syndrome 0.25% 1 in 400 680,000 rare
234. Ataxia Telangiectasia 0.25% 1 in 400 680,000 rare
235. Chediak-Higashi Syndrome 0.25% 1 in 400 680,000 rare
236. Machado-Joseph Disease 0.25% 1 in 400 680,000 rare
237. Kearns-Sayre Syndrome 0.25% 1 in 400 680,000 rare
238. Alpers Syndrome 0.25% 1 in 400 680,000 rare
239. Agnosia 0.25% 1 in 400 680,000 rare
240. Alexander Syndrome 0.25% 1 in 400 680,000 rare
241. Alternating Hemiplegia 0.25% 1 in 400 680,000 rare
242. Binswanger's Disease 0.25% 1 in 400 680,000 rare
243. Brown-Sequard Syndrome 0.25% 1 in 400 680,000 rare
244. Canavan disease 0.25% 1 in 400 680,000 rare
245. Coffin-Lowry syndrome 0.25% 1 in 400 680,000 rare
246. Fabry's Disease 0.25% 1 in 400 680,000 rare
247. Fahr's Syndrome 0.25% 1 in 400 680,000 rare
248. Hallervorden-Spatz disease 0.25% 1 in 400 680,000 rare
249. Incontinentia Pigmenti 0.25% 1 in 400 680,000 rare
250. Joubert Syndrome 0.25% 1 in 400 680,000 rare
251. Krabbé Disease 0.25% 1 in 400 680,000 rare
252. Landau-Kleffner Syndrome 0.25% 1 in 400 680,000 rare
253. Microcephaly 0.25% 1 in 400 680,000 rare
254. Miller Fisher Syndrome 0.25% 1 in 400 680,000 rare
255. Moyamoya Disease 0.25% 1 in 400 680,000 rare
256. Parry Romberg Syndrome 0.25% 1 in 400 680,000 rare
257. Pelizaeus-Merzbacher Disease 0.25% 1 in 400 680,000 rare
258. Primary Lateral Sclerosis 0.25% 1 in 400 680,000 rare
259. Progressive Supranuclear Palsy 0.25% 1 in 400 680,000 rare
260. Rasmussen's Encephalitis 0.25% 1 in 400 680,000 rare
261. Sandhoff Disease 0.25% 1 in 400 680,000 rare
262. Schilder's Disease 0.25% 1 in 400 680,000 rare
263. Septo-Optic Dysplasia 0.25% 1 in 400 680,000 rare
264. Soto's Syndrome 0.25% 1 in 400 680,000 rare
265. Stiff-Person Syndrome 0.25% 1 in 400 680,000 rare
266. Subacute Sclerosing Panencephalitis 0.25% 1 in 400 680,000 rare - because of the rarity of measles due to vaccination programs.
267. Williams Syndrome 0.25% 1 in 400 680,000 rare
268. Ménétrier's disease 0.25% 1 in 400 680,000 rare
269. Goodpasture syndrome 0.25% 1 in 400 680,000 rare.
270. Encephaloceles 0.25% 1 in 400 680,000 rare
271. Ramsay Hunt Syndrome Type 2 0.25% 1 in 400 680,000 rare
272. Mastocytosis 0.25% 1 in 400 680,000 rare
273. Cutaneous mastocytosis 0.25% 1 in 400 680,000 rare
274. Restrictive cardiomyopathy 0.25% 1 in 400 680,000 rare
275. Bacterial vaginosis 0.24% 1 in 424 640,000 16% of pregnant women (DSTD)
276. Polycystic kidney disease 0.22% 1 in 453 600,000 600,000 Americans
277. Inflammatory bowel disease 0.20% 1 in 500 544,000 1 in 500 (NIAID); 300,000 people to 500,000 people NIDDK
278. Autism 0.20% 1 in 500 544,000 1 in 500 to 1 in 2,500 (NIMH); 1-in-1000 to 2-in-1000, depending on diagnostic criteria
279. Nonaffective Psychosis 0.20% 1 in 500 544,000 estimated 0.2% adults (USSG)
280. Somatization Disorder 0.20% 1 in 500 544,000 estimated 0.2% adults (USSG)
281. Traumatic Brain Injury 0.20% 1 in 500 544,000 0.2% of population has an acquired brain injury in Australia 1998 (Australia’s Health 2004, AIHW)
282. Temporal arteritis 0.20% 1 in 500 544,000 200 per 100,000 people over 50.
283. Hypertrophic cardiomyopathy 0.20% 1 in 500 544,000 0.2 percent of the U.S. population
284. Autosomal dominant polycystic kidney disease 0.20% 1 in 503 540,000 540,000 Americans approximately (90% of PKD)
285. Crohn's disease 0.18% 1 in 544 500,000 500,000 Americans
286. Chronic Fatigue Syndrome 0.18% 1 in 544 500,000 500,000 Americans (CDC/NIAID)
287. Liver conditions 0.15% 1 in 679 400,000 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
288. Postpartum depression 0.15% 1 in 679 400,000 10% of pregnancies.
289. Chronic liver disease 0.15% 1 in 679 400,000 400,000 people
290. Cirrhosis of the liver 0.15% 1 in 679 400,000 400,000 people in the USA 1976-80 for "chronic liver disease and cirrhosis" (Digestive diseases in the United States: Epidemiology and Impact – NIH Publication No. 94-1447, NIDDK, 1994)
291. Ocular Herpes 0.15% 1 in 679 400,000 400,000 Americans have had some form
292. Pernicious anemia 0.15% 1 in 680 399,454 399,455 people in the USA 1996 1
293. End-stage renal disease 0.14% 1 in 693 392,022 392,023 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
294. Multiple Sclerosis 0.14% 1 in 700 388,571 1-in-700 (NIAID)
295. Triple-X syndrome 0.14% 1 in 700 388,571 1-in-700 approximately.
296. Ankylosing Spondylitis 0.13% 1 in 775 350,879 129 of every 100,000 people in the US (Mayo Clinic)
297. Type 1 diabetes 0.12% 1 in 800 340,000 1-in-800 (NIAID)
298. Scleroderma 0.11% 1 in 906 300,000 estimated 300,000 Americans (NWHIC)
299. Kidney Dialysis 0.11% 1 in 946 287,493 287,494 people in the USA 2001 (United States Renal Data System 2003 Annual Data Report, 2003)
300. Anorexia Nervosa 0.10% 1 in 1,000 272,000 estimated 0.1% adults (USSG); estimated 0.5 to 3.7 percent females (NIMH); 1% of adolescent girls (NWHIC)
301. Narcolepsy 0.07% 1 in 1,359 200,000 200,000 Americans (NHLBI estimate); 50,000 diagnosed.
302. Ménière's disease 0.05% 1 in 1,973 137,847 about 10,000 people in Australia
303. Autoimmune Lymphoproliferative Syndrome 0.05% 1 in 2,000 136,000 very rare; NIAID mentions 58 individuals
304. Neonatal lupus 0.05% 1 in 2,000 136,000 very rare
305. Jacobs syndrome 0.05% 1 in 2,000 136,000 1-in-2000 approximately.
306. Androgen Insensitivity Syndrome 0.05% 1 in 2,000 136,000 very rare
307. Porencephaly 0.05% 1 in 2,000 136,000 extremely rare
308. Schizencephaly 0.05% 1 in 2,000 136,000 extremely rare
309. Keratoconus 0.05% 1 in 2,000 136,000 1-in-2000 Americans
310. Retinitis Pigmentosa 0.04% 1 in 2,719 100,000 100,000 people have retinitis pigmentosa which can cause retinal deterioration and blindness in the US (Research to Prevent Blindness, NISE, NSF)
311. Vagina cancer 0.03% 1 in 3,333 81,600 3 in 10,000 for DES-related cases of vaginal cancer.
312. Diethylstilbestrol 0.03% 1 in 3,333 81,600 3 per 10,000 with a risk of vaginal cancer; probably higher if include other complications of DES
313. Sickle Cell Anemia 0.03% 1 in 3,777 72,000 72,000 people in USA (NHLBI); 2 million carriers (USA); 1 in 12 African American carriers
314. Familial emphysema 0.03% 1 in 3,885 70,000 70,000 Americans
315. Multiple Myeloma 0.02% 1 in 4,317 63,000 about 63,000 people affected by multiple myeloma ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
316. Primary Glomerulonephritis 0.02% 1 in 4,428 61,422 61,423 people with Primary Glomerulonephritis in the USA 1996 1
317. IgA nephropathy 0.02% 1 in 4,428 61,422 61,423 people in the USA 1996 1
318. Turner Syndrome 0.02% 1 in 5,000 54,400 1-in-5000
319. Sarcoidosis 0.02% 1 in 5,000 54,400 20 per 100,000 overall; 5 in 100,000 white people; 40 out of 100,000 black people; Scandinavia 64 out of 100,000 people
320. Marfan syndrome 0.02% 1 in 5,000 54,400 1 in 5,000 people in the USA
321. Ehlers-Danlos syndrome 0.02% 1 in 5,000 54,400 1 in 5,000 to 10,000 (Ehler's Danlos National Foundation)
322. Cardiomyopathy 0.02% 1 in 5,439 50,000 50,000 Americans (NHLBI)
323. Neonatal Respiratory Distress Syndrome 0.01% 1 in 6,800 40,000 40,000 infants and 150,000 adults with adult RDS (NHLBI)
324. Amyotrophic lateral sclerosis 0.01% 1 in 9,066 30,000 30,000 cases of ALS in America (Robert Packard Research Center at John Hopkins Hospital)
325. Cystic Fibrosis 0.01% 1 in 9,066 30,000 30,000 Americans (NIDDK)
326. Tuberous sclerosis 0.01% 1 in 10,000 27,200 less than 1 in 10,000
327. Uterine Cancer 0.01% 1 in 13,333 20,400 4,500 women in the UK 2001 (National Statistics, UK Government Census, 2001)
328. Hemophilia 0.01% 1 in 13,600 20,000 20,000 people in the United States (NHLBI)
329. Usher Syndrome 0.01% 1 in 17,000 16,000 16,000 Americans
330. Myasthenia Gravis 0.00% 1 in 20,000 13,600 about 5 per 100,000 to 14 per 100,000 (NWHIC)
331. Dermatomyositis 0.00% 1 in 20,205 13,461 13,462 people with polymyositis/dermatomyositis in the USA 1996 1
332. Acromegaly 0.00% 1 in 25,000 10,880 40-60 per million affected people at any time
333. Primary biliary cirrhosis 0.00% 1 in 29,462 9,231 9,232 people in the USA 1996 1
334. Multiple endocrine neoplasia type 1 0.00% 1 in 33,333 8,160 3 per 100,000 up to 20 per 100,000 (NIDDK)
335. Autoimmune uveitis 0.00% 1 in 58,658 4,637 4,637 people in the USA 1996 1
336. Corneal Dystrophies 0.00% 1 in 64,761 4,200 4,200 people have reduced vision because of corneal dystrophies in the US (Research to Prevent Blindness, NISE, NSF)
337. Amyloidosis 0.00% 1 in 90,666 3,000 less than 3,000 people in the US (Mayo Clinic)
338. Addison's Disease 0.00% 1 in 100,000 2,720 1 in 100,000; 13,335 people in the USA 1996 1
339. Guillain-Barre Syndrome 0.00% 1 in 100,000 2,720 about 1 in 100,000 (NWHIC)
340. X-Linked Agammaglobulinemia 0.00% 1 in 100,000 2,720 1-in-100,000
341. Autoimmune Hepatitis 0.00% 1 in 235,294 1,156 1,156 people in the USA 1996 1
342. Thalassemia 0.00% 1 in 272,000 1,000 1,000 people with Cooley's anemia (NHLBI)
343. Cryptococcosis 0.00% 1 in 500,000 544 0.2-0.9 cases per 100,000 in the general population (DBMD)
344. SCID 0.00% 1 in 500,000 543 approximately 1-per-500,000 (NIDCD); 1-per-million
345. Cushing's syndrome 0.00% 1 in 500,000 543 2-5 per million (NIDCD); 10 per million; 10-15 per million
346. Lymphangioleiomyomatosis 0.00% 1 in 544,000 500 Several hundred people in the USA (NHLBI)
347. Mucopolysaccharidosis I 0.00% 1 in 1.4 million 200 about 200 people ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
348. Glucagonoma 0.00% 1 in 2.7 million 100 only 100 cases since 1974 (Ganda, 1997)
349. POEMS 0.00% 1 in 2.7 million 100 about 100 known cases (Ganda [1997])
350. Chronic Granulomatous Disease 0.00% 1 in 4 million 67 1-in-4 million to 5 million (NIAID)
351. Rheumatic conditions 0.00% 1 in 6.3 million 43 nearly 43 Americans have arthritis or a rheumatic disease (CDC); 40 million people in the United States (NIAMS)
352. Somatostatinoma 0.00% 1 in 13.6 million 20 20 known cases in the literature (Ganda, 1997)
353. Pseudotumor Cerebri 0.00% 1 in 272 million 1 about 1-2 people per 100,000 population have benign intracranial hypertension in the US (Association for Spina Bifida and Hydrocephalus)


Footnotes:
1. Rose and Mackay, 1998, The Autoimmune Diseases, Third Edition

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