Complications of Kidney disease


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About complications: Complications of Kidney disease are secondary conditions, symptoms, or other disorders that are caused by Kidney disease. In many cases the distinction between symptoms of Kidney disease and complications of Kidney disease is unclear or arbitrary.

Complications list for Kidney disease: The list of complications that have been mentioned in various sources for Kidney disease includes:

Complications of Kidney disease: Normal kidneys filter excess proteins from the blood, thus preventing levels from getting too high. When the kidneys don't work properly, as in patients receiving dialysis, another type of protein called beta-2-microglobulin may build up in the blood. When this occurs, beta-2-microglobulin molecules may join together, like the links of a chain, forming a few very large molecules from many smaller ones. These large molecules can form deposits and eventually damage the surrounding tissues and cause great discomfort. This condition is called dialysis-related amyloidosis (DRA). 1

Anemia may begin to develop in the early stages of kidney disease, when you still have 20 percent to 50 percent of your normal kidney function. This partial loss of kidney function is often called chronic renal insufficiency. Anemia tends to worsen as kidney disease progresses. End-stage kidney failure, the point at which dialysis or kidney transplantation becomes necessary, doesn't occur until you have only about 10 percent of your kidney function remaining. Nearly everyone with end-stage kidney failure has anemia.2

If the kidneys are impaired, bones do not get enough calcium to grow. One reason is that the production of the vitamin D hormone may be deficient. Impaired kidneys may also let too much phosphorus build up in the blood; consequently, phosphorus keeps calcium from getting to the bones. 3

Footnotes:
1. excerpt from Amyloidosis and Kidney Disease: NIDDK
2. excerpt from Anemia in Kidney Disease and Dialysis: NIDDK
3. excerpt from Growth Failure in Children With Kidney Disease: NIDDK

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