Introduction: Germinal mosaicism


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Germinal mosaicism: Sometimes even an autosomal dominant disease can arise surprisingly when neither parent has the disease. This can be due to a mutation (see sporadic genetic disease), but need not be, and it can also be due to "germinal mosaicism". This is a condition where one parent's gamete cells have the genetic defect, whereas their normal cells do not. These conditions are very rare.

See also articles Introduction to Genetics and Introduction to Genetic Diseases.


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