Types of Creutzfeldt-Jakob Disease


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Types list: The list of types of Creutzfeldt-Jakob Disease mentioned in various sources includes:

  • Sporadic CJD - no family history, about 85% of cases
  • Hereditary CJD - genetic family history, 5-10%
  • Variant CJD - believed to be related to BSE
  • Acquired CJD - exposure to brain products, less than 1% of cases

Types discussion: There are three major categories of CJD:

  • In sporadic CJD, the disease appears even though the person has no known risk factors for the disease. This is by far the most common type of CJD and accounts for at least 85 percent of cases.
  • In hereditary CJD, the person has a family history of the disease and/or tests positive for a genetic mutation associated with CJD. About 5 to 10 percent of cases of CJD in the United States are hereditary.
  • In acquired CJD, the disease is transmitted by exposure to brain or nervous system tissue, usually through certain medical procedures. There is no evidence that CJD is contagious through casual contact with a CJD patient. Since CJD was first described in 1920, fewer than 1 percent of cases have been acquired CJD. 1

    There are three major categories of CJD: sporadic CJD, hereditary CJD, and acquired CJD. 2

    Footnotes:
    1. excerpt from Creutzfeldt-Jakob Disease Fact Sheet: NINDS
    2. excerpt from NINDS Creutzfeldt-Jakob Disease Information Page: NINDS

    Last revision: May 26, 2003

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