Inheritance and Genetics of Autoimmune Lymphoproliferative Syndrome


About inheritance and genetics: Inheritance of Autoimmune Lymphoproliferative Syndrome refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

Inheritance of Autoimmune Lymphoproliferative Syndrome: Children can inherit ALPS from one of their parents. The process of apoptosis is controlled by several genes. Most people with ALPS have an altered gene that plays a major role in apoptosis. The altered gene may be passed from one generation to the next. Before discussing what this gene does, we need to describe some basic information about genes and how they work.1

1. excerpt from Autoimmune Lymphoproliferative Syndrome (ALPS): NIAID

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